{"id":1885,"date":"2024-03-03T16:35:09","date_gmt":"2024-03-03T16:35:09","guid":{"rendered":"https:\/\/cake.appscodestudio.com\/?p=1885"},"modified":"2024-03-03T16:35:10","modified_gmt":"2024-03-03T16:35:10","slug":"ribozymes","status":"publish","type":"post","link":"https:\/\/cake.appscodestudio.com\/index.php\/2024\/03\/03\/ribozymes\/","title":{"rendered":"Ribozymes"},"content":{"rendered":"\n<p>Not all catalysis within the cell is carried out exclusively by proteins.\u00a0Thomas Cech\u00a0and\u00a0Sidney Altman, jointly awarded a\u00a0Nobel Prize\u00a0in 1989, discovered that certain RNAs, now known as ribozymes, showed enzymatic activity. Cech showed that a noncoding sequence (intron) in the small subunit rRNA of protozoans, which had to be removed before the rRNA was functional, can excise itself from a much longer\u00a0precursor\u00a0RNA\u00a0molecule\u00a0and rejoin the two ends in an autocatalytic reaction. Altman showed that the RNA component of an RNA protein complex called ribonuclease P can\u00a0<a href=\"https:\/\/www.merriam-webster.com\/dictionary\/cleave\">c<\/a>leave\u00a0a precursor tRNA to generate a mature tRNA. In addition to self-splicing RNAs similar to the one discovered by Cech, artificial RNAs have been made that show a variety of catalytic reactions. It is now widely held that there was a stage during evolution when only RNA catalyzed and stored genetic information. This period, sometimes called \u201cthe RNA world,\u201d is believed to have preceded the function of\u00a0DNA\u00a0as genetic material.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Not all catalysis within the cell is carried out exclusively by proteins.\u00a0Thomas Cech\u00a0and\u00a0Sidney Altman, jointly awarded a\u00a0Nobel Prize\u00a0in 1989, discovered that certain RNAs, now known as ribozymes, showed enzymatic activity. Cech showed that a noncoding sequence (intron) in the small subunit rRNA of protozoans, which had to be removed before the rRNA was functional, can [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-1885","post","type-post","status-publish","format-standard","hentry","category-nucleic-acids"],"Cooking_time":"","jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/posts\/1885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/comments?post=1885"}],"version-history":[{"count":1,"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/posts\/1885\/revisions"}],"predecessor-version":[{"id":1886,"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/posts\/1885\/revisions\/1886"}],"wp:attachment":[{"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/media?parent=1885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/categories?post=1885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cake.appscodestudio.com\/index.php\/wp-json\/wp\/v2\/tags?post=1885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}